Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases
Assessing the role played by purifying selection on a Susceptibility Allele to Late-Onset Disease (SALOD) is crucial to understand the puzzling allelic spectrum of a disease: most alleles are recent and rare. This fact is surprising, as it suggests that alleles are under purifying selection, while...
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| Pubblicato in: | URI:https://journals.openedition.org/bmsap, |
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| Autori principali: | , |
| Natura: | Article ou chapitre numérique |
| Lingua: | Anglais |
| Pubblicazione: |
Bulletins et mémoires de la société d’anthropologie de Paris
2021
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| Accesso online: | Accès Université d'Orléans et IFPM Accès Université d'Orléans et IFPM |
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openedition-oai:revues.org:bmsap_7154 |
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openedition |
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openedition-oai:revues.org:bmsap_7154 https://doi.org/10.4000/bmsap.7154 urn:doi:10.4000/bmsap.7154 en https://journals.openedition.org/bmsap/7154 2021-04-20T02:00:00Z info:eu-repo/semantics/openAccess article info:eu-repo/semantics/article urn:handle:20.500.13089/db5t https://creativecommons.org/licenses/by-nc-nd/4.0/ Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases Assessing the role played by purifying selection on a Susceptibility Allele to Late-Onset Disease (SALOD) is crucial to understand the puzzling allelic spectrum of a disease: most alleles are recent and rare. This fact is surprising, as it suggests that alleles are under purifying selection, while alleles that are involved in post-menopause mortality are often considered neutral in the genetic literature. The aim of this presentation is to use an evolutionary demography model in order to ass... Bulletins et mémoires de la société d’anthropologie de Paris Société d'Anthropologie de Paris info:eu-repo/semantics/reference/issn/1777-5469 info:eu-repo/semantics/reference/issn/0037-8984 URI:https://journals.openedition.org/bmsap Pavard, Samuel Coste, Christophe F.D. |
| collection |
OpenEdition Journal |
| language |
Anglais |
| format |
Article ou chapitre numérique |
| building |
0/Bibliothèque numérique/ 1/Bibliothèque numérique/OpenEdition Journals/ |
| description |
Assessing the role played by purifying selection on a Susceptibility Allele to Late-Onset Disease (SALOD) is crucial to understand the puzzling allelic spectrum of a disease: most alleles are recent and rare. This fact is surprising, as it suggests that alleles are under purifying selection, while alleles that are involved in post-menopause mortality are often considered neutral in the genetic literature. The aim of this presentation is to use an evolutionary demography model in order to ass... |
| author |
Pavard, Samuel Coste, Christophe F.D. |
| spellingShingle |
Pavard, Samuel Coste, Christophe F.D. Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases |
| author_facet |
Pavard, Samuel Coste, Christophe F.D. |
| author_sort |
Pavard, Samuel |
| title |
Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases |
| title_short |
Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases |
| title_full |
Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases |
| title_fullStr |
Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases |
| title_full_unstemmed |
Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases |
| title_sort |
evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases |
| publisher |
Bulletins et mémoires de la société d’anthropologie de Paris |
| publishDate |
2021 |
| container_title |
URI:https://journals.openedition.org/bmsap |
| url |
https://ezproxy.univ-orleans.fr/login?url=https://doi.org/10.4000/bmsap.7154 https://ezproxy.univ-orleans.fr/login?url=https://journals.openedition.org/bmsap/7154 |
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1877293643692244992 |