Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases
Assessing the role played by purifying selection on a Susceptibility Allele to Late-Onset Disease (SALOD) is crucial to understand the puzzling allelic spectrum of a disease: most alleles are recent and rare. This fact is surprising, as it suggests that alleles are under purifying selection, while...
Gespeichert in:
| Veröffentlicht in: | URI:https://journals.openedition.org/bmsap, |
|---|---|
| Hauptverfasser: | , |
| Format: | Article ou chapitre numérique |
| Sprache: | Anglais |
| Veröffentlicht: |
Bulletins et mémoires de la société d’anthropologie de Paris
2021
|
| Online Zugang: | Accès Université d'Orléans et IFPM Accès Université d'Orléans et IFPM |
| Zusammenfassung: | Assessing the role played by purifying selection on a Susceptibility Allele to Late-Onset Disease (SALOD) is crucial to understand the puzzling allelic spectrum of a disease: most alleles are recent and rare. This fact is surprising, as it suggests that alleles are under purifying selection, while alleles that are involved in post-menopause mortality are often considered neutral in the genetic literature. The aim of this presentation is to use an evolutionary demography model in order to ass... |
|---|