Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats
The objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related protein levels in rats. Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet s...
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| フォーマット: | Article ou chapitre numérique |
| 言語: | Français |
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2021
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| オンライン･アクセス: | Accès Université d'Orléans et IFPM Accès Université d'Orléans et IFPM |
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cairn-MRH_341_0009MRHMagnesium Research https://stm.cairn.info/revue-magnesium-research-2021-1-page-9?lang=en https://doi.org/10.1684/mrh.2021.0480 Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats Sahin, KazimOrhan, CemalKucuk, OsmanErten, FusunTuzcu, MehmetSahin, NurhanPerez Ojalvo, SaraKomorowski, James Richard2021 D-biotinglucoseinsulinlipid parametersmagnesium biotinatefre Magnesium Research | 34 | 1 | 2021-01-01 | p. 9-19 | 0953-1424 MRH_34196 The objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related protein levels in rats. Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet supplemented with either d-biotin at 0.01, 1, or 100 mg/kg BW or magnesium biotinate at 0.01, 1, or 100 mg/kg BW for 35 days. Neither form of biotin influenced (p > 0.05) serum glucose or insulin concentrations. Serum total cholesterol and triglyceride decreased with biotin from both sources (p < 0.05). Concentrations were lower with magnesium biotinate when comparing the 1 mg/kg dose (p < 0.05). Serum, liver, and brain biotin and liver cyclic guanosine monophosphate (cGMP) concentrations were greater when rats were treated with magnesium biotinate versus d-biotin, particularly when comparing the 1 and 100 mg/kg dose groups (p < 0.05). Both biotin forms decreased the liver SREBP-1c and FAS and increased AMPK-α1, ACC-1, ACC-2, PCC, and MCC levels (p < 0.05). The magnitudes of responses were more emphasized with magnesium biotinate. Magnesium biotinate, compared with a commercial d-biotin, is more effective in reducing serum lipid concentrations and regulating protein levels of lipid metabolism-related biomarkers.Cairn free access |
| language |
Français |
| format |
Article ou chapitre numérique |
| building |
0/Bibliothèque numérique/ 1/Bibliothèque numérique/Cairn/ |
| topic |
D-biotin glucose insulin lipid parameters magnesium biotinate |
| spellingShingle |
D-biotin glucose insulin lipid parameters magnesium biotinate Sahin, Kazim Orhan, Cemal Kucuk, Osman Erten, Fusun Tuzcu, Mehmet Sahin, Nurhan Perez Ojalvo, Sara Komorowski, James Richard Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats |
| topic_facet |
D-biotin glucose insulin lipid parameters magnesium biotinate |
| description |
The objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related protein levels in rats. Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet supplemented with either d-biotin at 0.01, 1, or 100 mg/kg BW or magnesium biotinate at 0.01, 1, or 100 mg/kg BW for 35 days. Neither form of biotin influenced (p > 0.05) serum glucose or insulin concentrations. Serum total cholesterol and triglyceride decreased with biotin from both sources (p < 0.05). Concentrations were lower with magnesium biotinate when comparing the 1 mg/kg dose (p < 0.05). Serum, liver, and brain biotin and liver cyclic guanosine monophosphate (cGMP) concentrations were greater when rats were treated with magnesium biotinate versus d-biotin, particularly when comparing the 1 and 100 mg/kg dose groups (p < 0.05). Both biotin forms decreased the liver SREBP-1c and FAS and increased AMPK-α1, ACC-1, ACC-2, PCC, and MCC levels (p < 0.05). The magnitudes of responses were more emphasized with magnesium biotinate. Magnesium biotinate, compared with a commercial d-biotin, is more effective in reducing serum lipid concentrations and regulating protein levels of lipid metabolism-related biomarkers. |
| author |
Sahin, Kazim Orhan, Cemal Kucuk, Osman Erten, Fusun Tuzcu, Mehmet Sahin, Nurhan Perez Ojalvo, Sara Komorowski, James Richard |
| author_facet |
Sahin, Kazim Orhan, Cemal Kucuk, Osman Erten, Fusun Tuzcu, Mehmet Sahin, Nurhan Perez Ojalvo, Sara Komorowski, James Richard |
| author_sort |
Sahin, Kazim |
| title |
Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats |
| title_short |
Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats |
| title_full |
Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats |
| title_fullStr |
Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats |
| title_full_unstemmed |
Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats |
| title_sort |
effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats |
| publishDate |
2021 |
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| url |
https://ezproxy.univ-orleans.fr/login?url=https://stm.cairn.info/revue-magnesium-research-2021-1-page-9?lang=en https://ezproxy.univ-orleans.fr/login?url=https://doi.org/10.1684/mrh.2021.0480 |
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1877246235877834752 |