Contrast agents. I, magnetic resonance imaging

Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a...

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1. Verfasser: Krause, Werner, 1949-
Format: Livre numérique
Sprache:Anglais
Veröffentlicht: Berlin [etc.] : Springer [20..].
Cham : Springer Nature
Schriftenreihe:Topics in current chemistry 221
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Edition sous un autre format:• Contrast agents, I, magnetic resonance imaging, volume editor : Werner Krause, 2002, Berlin, Springer, 1 vol. (VIII-249 p.), Topics in current chemistry, 3-540-42247-1
• Contrast Agents I, Texte imprimé, 9783642075964
• Contrast Agents I, Texte imprimé, 9783662146538
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505 0 |a Extracellular MRI Contrast Agents Based on Gadolinium -- Structures of MRI Contrast Agents in Solution -- Relaxivity of MRI Contrast Agents -- Kinetic Stabilities of Gadolinium(III) Chelates Used as MRI Contrast Agents -- New Classes of MRI Contrast Agents -- Non-Gadolinium-Based MRI Contrast Agents -- Blood-Pool MRI Contrast Agents: Properties and Characterization. 
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520 |a Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1 2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1]. 
650 |a Produits de contraste 
650 |a Imagerie par résonance magnétique 
650 |a Gadolinium  |x Emploi en diagnostic 
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