Coarse-grained modelling of DNA and DNA self-assembly

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of s...

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Hlavní autor: Ouldridge, Thomas E., 19..-
Médium: Livre numérique
Jazyk:Anglais
Vydáno: Berlin, Heidelberg : Springer Berlin Heidelberg [20..].
Cham : Springer Nature
Vydání:1st ed. 2012.
Edice:Springer Theses, Recognizing Outstanding Ph.D. Research
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Poznámka: Archives Springer e-books (Licence nationale)
Archives Springer e-books (Licence nationale)
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Edition sous un autre format:• Coarse-Grained Modelling of DNA and DNA Self-Assembly, Texte imprimé, 9783642305160
• Coarse-Grained Modelling of DNA and DNA Self-Assembly, Texte imprimé, 9783642305184
• Coarse-Grained Modelling of DNA and DNA Self-Assembly, Texte imprimé, 9783642436529
• Coarse-Grained Modelling of DNA and DNA Self-Assembly, Texte imprimé, 9783642305160
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Shrnutí:This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology
Popis jednotky:Archives Springer e-books (Licence nationale)
Archives Springer e-books (Licence nationale)
ISBN:9783642305177
ISSN:2190-5061
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