Metallocorroles for attenuation of atherosclerosis
Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atheroscler...
Uloženo v:
| Hlavní autor: | |
|---|---|
| Médium: | Livre numérique |
| Jazyk: | Anglais |
| Vydáno: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| Vydání: | 1st ed. 2012. |
| Edice: | Springer Theses, Recognizing Outstanding Ph.D. Research
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| On-line přístup: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| Poznámka: |
Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Metallocorroles for Attenuation of Atherosclerosis, Texte imprimé, 9783642303272 • Metallocorroles for Attenuation of Atherosclerosis, Texte imprimé, 9783642303296 • Metallocorroles for Attenuation of Atherosclerosis, Texte imprimé, 9783642442506 • Metallocorroles for Attenuation of Atherosclerosis, Texte imprimé, 9783642303272 |
Obsah:
- Biologically relevant ROS/RNS Atherosclerosis The pro-atherogenic role of LDL and macrophages The anti-atheroginicity of HDL Common treatments for atherosclerosis Corroles Catalytic antioxidants Electronic spectra Research Goals Results Interactions of corroles with lipoproteins Corrole-lipoproteins binding Corrole distribution in serum Spectral changes in the presence of lipoprotein components The effect of corroles on oxidative-stress-induced lipoprotein damage Cu+2-induced oxidation Peroxynitrite-induced oxidation Lipoprotein function Interactions of corroles with macrophages Fluorescence-based detection of 1-Ga Chemiluminescence-based detection of 1-Fe Cellular accumulation of 1-Fe versus iron(III) porphyrins The effect of corroles on macrophage atherogenicity Effect on oxidative-stress-induced cell death Effect on macrophages cholesterol metabolism.-The effect of corroles on the development of atherosclerosis Discussion Interaction of corroles with lipoproteins Corrole distribution in serum Mode of 1-Fe binding to lipoproteins Materials and Methods