Metallocorroles for attenuation of atherosclerosis
Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atheroscler...
Bewaard in:
| Hoofdauteur: | |
|---|---|
| Formaat: | Livre numérique |
| Taal: | Anglais |
| Gepubliceerd in: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| Editie: | 1st ed. 2012. |
| Reeks: | Springer Theses, Recognizing Outstanding Ph.D. Research
|
| Online toegang: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| Opmerking: |
Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Metallocorroles for Attenuation of Atherosclerosis, Texte imprimé, 9783642303272 • Metallocorroles for Attenuation of Atherosclerosis, Texte imprimé, 9783642303296 • Metallocorroles for Attenuation of Atherosclerosis, Texte imprimé, 9783642442506 • Metallocorroles for Attenuation of Atherosclerosis, Texte imprimé, 9783642303272 |
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| 008 | 130325q2000 xx ||| |||| 00| 0 eng d | ||
| 009 | PPN168316439 | ||
| 020 | |a 9783642303289 | ||
| 041 | 0 | |a eng | |
| 082 | |a 547.05 | ||
| 100 | 1 | |a Haber, Adi, |d 19..- | |
| 245 | 1 | 0 | |a Metallocorroles for attenuation of atherosclerosis |c by Adi Haber. |
| 250 | |a 1st ed. 2012. | ||
| 260 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg. | ||
| 260 | |a Cham : |b Springer Nature, |c [20..]. | ||
| 490 | 0 | |a Springer Theses, Recognizing Outstanding Ph.D. Research |x 2190-5061 | |
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 505 | 1 | |a Biologically relevant ROS/RNS Atherosclerosis The pro-atherogenic role of LDL and macrophages The anti-atheroginicity of HDL Common treatments for atherosclerosis Corroles Catalytic antioxidants Electronic spectra Research Goals Results Interactions of corroles with lipoproteins Corrole-lipoproteins binding Corrole distribution in serum Spectral changes in the presence of lipoprotein components The effect of corroles on oxidative-stress-induced lipoprotein damage Cu+2-induced oxidation Peroxynitrite-induced oxidation Lipoprotein function Interactions of corroles with macrophages Fluorescence-based detection of 1-Ga Chemiluminescence-based detection of 1-Fe Cellular accumulation of 1-Fe versus iron(III) porphyrins The effect of corroles on macrophage atherogenicity Effect on oxidative-stress-induced cell death Effect on macrophages cholesterol metabolism.-The effect of corroles on the development of atherosclerosis Discussion Interaction of corroles with lipoproteins Corrole distribution in serum Mode of 1-Fe binding to lipoproteins Materials and Methods | |
| 506 | |a Accès en ligne pour les établissements français bénéficiaires des licences nationales | ||
| 506 | |a Accès soumis à abonnement pour tout autre établissement | ||
| 506 | |a Conditions particulières de réutilisation pour les bénéficiaires des licences nationales. https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 | ||
| 520 | |a Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases | ||
| 776 | 0 | |t Metallocorroles for Attenuation of Atherosclerosis |b Texte imprimé |z 9783642303272 | |
| 776 | 0 | |t Metallocorroles for Attenuation of Atherosclerosis |b Texte imprimé |z 9783642303296 | |
| 776 | 0 | |t Metallocorroles for Attenuation of Atherosclerosis |b Texte imprimé |z 9783642442506 | |
| 776 | 0 | |t Metallocorroles for Attenuation of Atherosclerosis |b Texte imprimé |z 9783642303272 | |
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| 856 | 4 | |5 180339901:752167804 |u https://ezproxy.insa-cvl.fr/login?qurl=https://dx.doi.org/10.1007/978-3-642-30328-9 |z Accès INSA CVL | |
| 997 | |0 958328 |1 Livre numérique |a Ressource numérique |b INSA |b ENSA |c 0/Bibliothèque numérique/ |c 1/Bibliothèque numérique/Autre ressource numérique/ | ||