Bioactive Conformation II
Speci?c binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term bioac...
Gardado en:
| Autor Principal: | |
|---|---|
| Formato: | Livre numérique |
| Idioma: | Anglais |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| Edición: | 1st ed. 2008. |
| Series: | Topics in Current Chemistry
273 |
| Sujets: | |
| Acceso en liña: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| Nota: |
Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Bioactive conformation, II, volume editor : Thomas Peters, Berlin, Springer, 2008, 1 vol. (XII-233 p.), Topics in current chemistry, 978-3-540-49079-1 |
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| 100 | 1 | |a Peters, Thomas. | |
| 245 | 1 | 0 | |a Bioactive Conformation II |c edited by Thomas Peters. |
| 250 | |a 1st ed. 2008. | ||
| 260 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg. | ||
| 260 | |a Cham : |b Springer Nature, |c [20..]. | ||
| 490 | 0 | |a Topics in Current Chemistry |v 273 |x 1436-5049 | |
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 505 | 1 | |a NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands Quantitative Analysis of STD-NMR Spectra of Reversibly Forming Ligand Receptor Complexes Structural and Functional Studies of Peptide Carbohydrate Mimicry Studies on the Conformational Features of Neomycin-B and its Molecular Recognition by RNA and Bacterial Defense Proteins Solid State NMR Structure Analysis of the Antimicrobial Peptide Gramicidin S in Lipid Membranes: Concentration-Dependent Re-alignment and Self-Assembly as a ?-Barrel Modulation of the Bioactive Conformation of Transforming Growth Factor ?: Possible Implications of Cation Binding for Biological Function Molecular Recognition of Ligands by Native Viruses and Virus-Like Particles as Studied by NMR Experiments Investigation of Proteins in Living Bacteria with In-Cell NMR Experiments | |
| 506 | |a Accès en ligne pour les établissements français bénéficiaires des licences nationales | ||
| 506 | |a Accès soumis à abonnement pour tout autre établissement | ||
| 506 | |a Conditions particulières de réutilisation pour les bénéficiaires des licences nationales. https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 | ||
| 520 | |a Speci?c binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term bioactive conformation usually characterizes the conformation of a ligand when it is bound to a receptor. In a more general sense, bioactive conformation applies toanymoleculeinabiologicallyrelevantboundstateregardlessofsizecons- erations. Mostofthecontributions tothisbookaddressligandsthat aremuch smaller than their receptors. X-ray crystallography and high resolution NMR spectroscopy are the two main experimental techniques used to study bioactive conformations. The- fore,the twovolumes ofthisbookcover approachesthat use either ofthetwo techniques, or a combination thereof. The combination of X-ray crystallog- phy and NMR spectroscopy is particularly useful when a crystal structure of areceptorprotein,butnotofthereceptorprotein ligandcomplex,isavailable. Anumberofexperimentaltechniquestoanalyzethebioactiveconformationof aligandwithNMRarebasedontheobservationoftheresonancesignalsofthe free ligand that is in exchange with the bound ligand. Several chapters focus onsuchapproachesthat rangefrom classical transferredNOEexperiments, totransferred dipolar couplings,toSTD (saturation transfer difference) NMR techniques. Incaseswhere tightbinding inthesub-nanomolar rangeprevents the analysis of the bioactive conformation via free ligand signals, the ligand proteincomplexhas tobeanalyzed withproteinNMR-based techniques orby crystallography.Sincethisareahasbeenthesubjectofmanyreviewsandmo- graphsitwill not be covered here in particular detail. As a unifying theme, all contributionstargetthequestionofhowmolecular recognitionofbiologically active molecules is achieved on the atomic scale. Depending on the research topic the results from these studies have a strong impact not only in basic research but also in several ?elds of application ranging frompharmaceutical applications tothe use of biomolecules as, for example, cryoprotectants | ||
| 650 | |a Biomolécules actives | ||
| 650 | |a Reconnaissance moléculaire | ||
| 650 | |a Chimie pharmaceutique | ||
| 650 | |a Spectroscopie de la résonance magnétique nucléaire | ||
| 650 | |a Radiocristallographie | ||
| 650 | |a Chimie | ||
| 650 | |a Complexes récepteur-ligand | ||
| 650 | |a Chimie organique | ||
| 650 | |a Ligands (biochimie) | ||
| 650 | |a Biochimie | ||
| 650 | |a Chimie physique et théorique | ||
| 650 | |a Chimie analytique | ||
| 650 | |a Ligands (biochimie) |x Fixation | ||
| 650 | |a Analyse conformationnelle | ||
| 650 | |a Conformation | ||
| 776 | 0 | |0 128246642 |t Bioactive conformation |h II |f volume editor : Thomas Peters |c Berlin |n Springer |d 2008 |p 1 vol. (XII-233 p.) |s Topics in current chemistry |z 978-3-540-49079-1 | |
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| 856 | 4 | |u https://revue-sommaire.istex.fr/ark:/67375/8Q1-5TXP4G5N-N |z Accès sur la plateforme Istex | |
| 856 | 4 | |5 452349901:747853940 |u https://ezproxy.univ-orleans.fr/login?url=https://dx.doi.org/10.1007/978-3-540-49080-7 |z Accès Université d'Orléans | |
| 856 | 4 | |5 180339901:750871466 |u https://ezproxy.insa-cvl.fr/login?qurl=https://dx.doi.org/10.1007/978-3-540-49080-7 |z Accès INSA CVL | |
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