Problems of High Altitude Medicine and Biology
The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth mu...
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| 団体著者: | |
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| その他の著者: | , |
| フォーマット: | Livre numérique |
| 言語: | Anglais |
| 出版事項: |
Dordrecht :
Springer Netherlands
[20..].
Cham : Springer Nature |
| シリーズ: | NATO science for peace and security series. A, Chemistry and biology
NATO Science for Peace and Security Series A: Chemistry and Biology |
| 主題: | |
| オンライン･アクセス: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| 注記: |
L'impression du document génère 300 p. Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Variante du titre: | Proceedings of the NATO Advanced Research Workshop on Problems of High Altitude Medicine and Biology, Issyk-Kul, Kyrgyz Republic, 5-6 June 2006 |
| Edition sous un autre format: | • Problems of high altitude medicine and biology, edited by Almaz Aldashev, Robert Naeije, Dordrecht, Springer, 2007, 1 vol. (VIII-306 p.), NATO science for peace and security series, 978-1-402-06298-8 |
| 要約: | The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20] |
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| 記述事項: | L'impression du document génère 300 p. Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| 書誌: | Bibliogr. en fin de contributions. Index |
| ISBN: | 9781402063008 |
| ISSN: | 1874-6527 1874-6489 |
| アクセス: | Accès en ligne pour les établissements français bénéficiaires des licences nationales Accès soumis à abonnement pour tout autre établissement Conditions particulières de réutilisation pour les bénéficiaires des licences nationales. https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 |