Systemic Sclerosis
Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has ye...
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| Jazyk: | Anglais |
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2021
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| On-line přístup: | Accès Université d'Orléans et IFPM Accès INSA CVL |
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doab-20.500.12854_655212024-03-31T22:43:51Z Systemic Sclerosis Radstake, Timothy Immunology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has yet to be determined: endothelial dysfunction, autoantibody formation, and activation of fibroblasts. This current book provides up-to-date information on the pathogenesis and clinical features of this severe syndrome. It is our hope that this book will aid both clinicians and researchers in dealing with patients with this clinical syndrome. In addition, we hope to shed more light on this rare and severely disabling syndrome, ultimately leading to better research and successful therapeutic targeting. 2021-04-20T15:19:20Z 2021-04-20T15:19:20Z 2012 book ONIX_20210420_9789533078694_878 9789533078694 9789535167372 https://directory.doabooks.org/handle/20.500.12854/65521 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/817/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/1326 10.5772/1326 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789533078694 9789535167372 IntechOpen 220 open access |
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INSA |
| collection |
DOAB |
| language |
Anglais |
| topic |
Immunology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| spellingShingle |
Immunology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology Systemic Sclerosis |
| description |
Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has yet to be determined: endothelial dysfunction, autoantibody formation, and activation of fibroblasts. This current book provides up-to-date information on the pathogenesis and clinical features of this severe syndrome. It is our hope that this book will aid both clinicians and researchers in dealing with patients with this clinical syndrome. In addition, we hope to shed more light on this rare and severely disabling syndrome, ultimately leading to better research and successful therapeutic targeting. |
| author2 |
Radstake, Timothy |
| author_facet |
Radstake, Timothy |
| title |
Systemic Sclerosis |
| title_short |
Systemic Sclerosis |
| title_full |
Systemic Sclerosis |
| title_fullStr |
Systemic Sclerosis |
| title_full_unstemmed |
Systemic Sclerosis |
| title_sort |
systemic sclerosis |
| publisher |
IntechOpen |
| publishDate |
2021 |
| url |
https://ezproxy.univ-orleans.fr/login?url=https://directory.doabooks.org/handle/20.500.12854/65521 https://ezproxy.insa-cvl.fr/login?url=https://directory.doabooks.org/handle/20.500.12854/65521 |
| _version_ |
1877238568970092544 |