Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy

In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EP...

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書誌詳細
第一著者: J.N.Junk, Matthias
フォーマット: Livre numérique
言語:Anglais
出版事項: Berlin, Heidelberg : Springer Berlin Heidelberg 2012.
Cham : Springer Nature
シリーズ:Springer Theses, Recognizing Outstanding Ph.D. Research
オンライン・アクセス:Accès sur la plateforme de l'éditeur
Accès sur la plateforme Istex
Accès Université d'Orléans
Accès INSA CVL
注記: Archives Springer e-books (Licence nationale)
Archives Springer e-books (Licence nationale)
Autres localisations: Voir dans le Sudoc
Edition sous un autre format:• Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy, Texte imprimé, 9783642251344
• Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy, Texte imprimé, 9783642251368
• Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy, Texte imprimé, 9783642437953
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505 0 |a Electron Paramagnetic Resonance Theory -- The Functional Structure of Human Serum Albumin -- Copper Complexes of Star-Shaped Cholic Acid Oligomers with 1,2,3-Triazole Moieties -- Nano-Inhomogeneities in Structure and Reactivity  of Thermoresponsive Hydrogels -- Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents -- Local Nanoscopic Heterogeneities in Thermoresponsive Dendronized Polymers. 
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520 |a In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure a consequence of the protein s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material s hosting properties and enable unforeseen complex catalytic functionalities. 
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