Heteroaromatic Lipoxin A4 Analogues : Synthesis and Biological Evaluation
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines kno...
Gorde:
| Egile nagusia: | |
|---|---|
| Formatua: | Livre numérique |
| Hizkuntza: | Anglais |
| Argitaratua: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| Edizioa: | 2012. |
| Saila: | Springer Theses, Recognizing Outstanding Ph.D. Research
|
| Sarrera elektronikoa: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| Oharra: |
Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Heteroaromatic Lipoxin A4 Analogues, Texte imprimé, 9783642246319 |
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| 020 | |a 9783642246326 | ||
| 041 | 0 | |a eng | |
| 082 | |a 547 | ||
| 100 | 1 | |a Duffy, Colm. | |
| 245 | 1 | 0 | |a Heteroaromatic Lipoxin A4 Analogues : |b Synthesis and Biological Evaluation |c by Colm Duffy. |
| 250 | |a 2012. | ||
| 260 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg. | ||
| 260 | |a Cham : |b Springer Nature, |c [20..]. | ||
| 490 | 0 | |a Springer Theses, Recognizing Outstanding Ph.D. Research |x 2190-5061 | |
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 505 | 1 | |a Introduction Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines Towards the synthesis of various heteroaromatic Lipoxin A4 analogues | |
| 506 | |a Accès en ligne pour les établissements français bénéficiaires des licences nationales | ||
| 506 | |a Accès soumis à abonnement pour tout autre établissement | ||
| 506 | |a Conditions particulières de réutilisation pour les bénéficiaires des licences nationales. https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 | ||
| 520 | |a In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation | ||
| 776 | 0 | |t Heteroaromatic Lipoxin A4 Analogues |b Texte imprimé |z 9783642246319 | |
| 856 | 4 | |q PDF |u https://doi.org/10.1007/978-3-642-24632-6 |z Accès sur la plateforme de l'éditeur | |
| 856 | 4 | |u https://revue-sommaire.istex.fr/ark:/67375/8Q1-7QR95G3W-S |z Accès sur la plateforme Istex | |
| 856 | 4 | |5 452349901:750603534 |u https://ezproxy.univ-orleans.fr/login?url=https://dx.doi.org/10.1007/978-3-642-24632-6 |z Accès Université d'Orléans | |
| 856 | 4 | |5 180339901:753963779 |u https://ezproxy.insa-cvl.fr/login?qurl=https://dx.doi.org/10.1007/978-3-642-24632-6 |z Accès INSA CVL | |
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