Metallointercalators : Synthesis and Techniques to Probe Their Interactions with Biomolecules

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and imp...

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Opis bibliograficzny
1. autor: Aldrich-Wright, Janice, 19..- (Redaktor)
Format: Livre numérique
Język:Anglais
Wydane: Vienna : Springer Vienna [20..].
Cham : Springer Nature
Wydanie:1st ed. 2011.
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Edition sous un autre format:• Metallointercalators, synthesis and techniques to probe their interactions with biomolecules, Janice Aldrich-Wright, editor, Wien, Springer, 2011, 1 vol. (xxviii-427 p.), 978-3-211-09427-3
Spis treści:
  • Introduction Synthesis:Platinum Intercalating Complexes; Binuclear Platinum Complexes;Binuclear Ruthenium and Platinum Intercalating Complexes; Sequence Selective Intercalating Complexes; Targeting and Improving Transport, Cucurbit[n]uril, Cylcodextrin and Dendrimers Techniques to Probe Interactions with Biomolecules:Introduction to NMR; DNA-NMR; PGSE-NMR; DNA ESI-MS; Investigating Binding Interactions using Linear Dichromism and Circular Dichromism; Flourescence Spectroscopy; Confocal Microscopy; Implementation of synchotron X-ray microscopy for investigations of the cellular uptake and cellular metabolism of metallointercalators; Biomolecular Helical Structure; Viscosity, TGA and Dialysis; Microarrays; Cytotoxicity-Cell lines; Antibacterical activity; Animal testing