Formation and cooperative behaviour of protein complexes on the cell membrane
With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It...
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| Materialtyp: | Thèse numérique |
| Språk: | Anglais |
| Publicerad: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| Upplaga: | 1st ed. 2012. |
| Serie: | Springer Theses, Recognizing Outstanding Ph.D. Research
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| Ämnen: | |
| Länkar: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| Anmärkning: |
Pagination aprés impression : XII-80 p. Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Formation and cooperative behaviour of protein complexes on the cell membrane, Texte imprimé • Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane, Texte imprimé, 9783642269943 • Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane, Texte imprimé, 9783642239878 • Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane, Texte imprimé, 9783642239892 |
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| 100 | 1 | |a Guseva, Ksenia. | |
| 245 | 1 | 0 | |a Formation and cooperative behaviour of protein complexes on the cell membrane |c Ksenia Guseva. |
| 250 | |a 1st ed. 2012. | ||
| 260 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg. | ||
| 260 | |a Cham : |b Springer Nature, |c [20..]. | ||
| 490 | 0 | |a Springer Theses, Recognizing Outstanding Ph.D. Research |x 2190-5061 | |
| 500 | |a Pagination aprés impression : XII-80 p. | ||
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 502 | |a Thèse de doctorat, biologie, Institute of complex systems and mathematical biology, université de Aberdeen, Royaume-Uni, 2011 | ||
| 504 | |a Bibliogr. en fin de chapitre | ||
| 505 | 1 | |a Introduction The Role of Fragmentation on the Formation of Homomeric Protein Complexes Collective Response of Self-organised Clusters of Mechanosensitive Channels Assembly and Fragmentation of Tat Pores Conclusion. | |
| 506 | |a Accès en ligne pour les établissements français bénéficiaires des licences nationales | ||
| 506 | |a Accès soumis à abonnement pour tout autre établissement | ||
| 506 | |a Conditions particulières de réutilisation pour les bénéficiaires des licences nationales. https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 | ||
| 520 | |a With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process. | ||
| 650 | |a Protéines membranaires | ||
| 650 | |a Membrane cellulaire | ||
| 776 | 0 | |t Formation and cooperative behaviour of protein complexes on the cell membrane |b Texte imprimé | |
| 776 | 0 | |t Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane |b Texte imprimé |z 9783642269943 | |
| 776 | 0 | |t Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane |b Texte imprimé |z 9783642239878 | |
| 776 | 0 | |t Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane |b Texte imprimé |z 9783642239892 | |
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