Tetramer stability and functional regulation of tumor suppressor protein p53
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a k...
Bewaard in:
| Hoofdauteur: | |
|---|---|
| Formaat: | Livre numérique |
| Taal: | Anglais |
| Gepubliceerd in: |
Tokyo :
Springer Japan
[20..].
Cham : Springer Nature |
| Editie: | 1st ed. 2012. |
| Reeks: | Springer Theses, Recognizing Outstanding Ph.D. Research
|
| Online toegang: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| Opmerking: |
Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53, Texte imprimé, 9784431541349 • Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53, Texte imprimé, 9784431541363 • Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53, Texte imprimé, 9784431547259 • Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53, Texte imprimé, 9784431541349 |
Inhoudsopgave:
- Quantitative analysis for p53 tetramerization domain mutants reveals a low threshold for tumor suppressor inactivation Stabilization of mutant tetrameric structures by calixarene derivatives Inhibition of the transcriptional activity of p53 through hetero-oligomerization