Transformative Concepts for Drug Design: Target Wrapping
In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful t...
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| Главный автор: | |
|---|---|
| Формат: | Livre numérique |
| Язык: | Anglais |
| Опубликовано: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| Online-ссылка: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| Примечание: |
Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Transformative Concepts for Drug Design: Target Wrapping, Texte imprimé, 9783642117916 |
Оглавление:
- Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy Wrapping Defects and the Architecture of Soluble Proteins Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design Under-Wrapped Proteins in the Order Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation Evolution of Protein Wrapping and Implications for the Drug Designer Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact Inducing Folding By Crating the Target Wrapper Drugs as Therapeutic Editors of Side Effects Wrapper Drugs for Personalized Medicine Last Frontier and Back to the Drawing Board: Protein Water Interfacial Tension in Drug Design