Statistics in clinical vaccine trials
This monograph offers well-founded training and expertise on the statistical analysis of data from clinical vaccine trials, i.e., immunogenicity and vaccine field efficacy studies. The book's scope is practical rather than theoretical. It opens with two introductory chapters on the immunology o...
Enregistré dans:
| Auteur principal: | |
|---|---|
| Format: | Livre numérique |
| Langue: | Anglais |
| Publié: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| Édition: | 1st ed. 2011. |
| Accès en ligne: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| Note: |
Description d'après consultation du 22 avril 2013 Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Statistics in clinical vaccine trials, Jozef Nauta, Heidelberg [etc.], Springer, 2011, 1 vol. (XVIII-153 pages), 978-3-642-14690-9 |
Table des matières:
- Basic Concepts of Vaccine Immunology Humoral and Cellular Immunity Standard Statistical Methods for the Analysis of Immunogenicity Data Antibody Titres and Two Types of Bias Adjusting for Imbalance in Pre-vaccination State Vaccine Equivalence and Non-Inferiority Immunogenicity Trials Vaccine Field Efficacy Trials Correlates of Protection Safety of Vaccines Appendices: SAS and Floating Point Format for Calculated Variables Closed-Form Solutions for the Constrained ML Estimators Ro Simulation Results on Jewell s Correction for the Rate Ratio Proof of Inequality A Generalized Worst-Case Sensitivity Analysis for a Single Seroresponse Rate for Which the Confidence Interval Must Fall Above a Pre-Specified Bound