Tubulin-Binding Agents : Synthetic, Structural and Mechanistic Insights
reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year pe...
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| Glavni autor: | |
|---|---|
| Format: | Livre numérique |
| Jezik: | Anglais |
| Izdano: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| Izdanje: | 1st ed. 2009. |
| Serija: | Topics in Current Chemistry
286 |
| Teme: | |
| Online pristup: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| Bilješka: |
Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Tubulin-binding agents, synthetic, structural and mechanistic insights, Volume Editor : Teresa Carlomagno, Berlin, Springer, 2009, 1 vol. (XI- 331 p.), Topics in current chemistry, 978-3-540-69036-8 |
Sadržaj:
- Macrolide-Based Microtubule-Stabilizing Agents Chemistry and Structure Activity Relationships The Chemical Synthesis of Discodermolide The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents