Tubulin-Binding Agents : Synthetic, Structural and Mechanistic Insights
reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year pe...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | Livre numérique |
| اللغة: | Anglais |
| منشور في: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| الطبعة: | 1st ed. 2009. |
| سلاسل: | Topics in Current Chemistry
286 |
| الموضوعات: | |
| الوصول للمادة أونلاين: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| ملاحظة: |
Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Tubulin-binding agents, synthetic, structural and mechanistic insights, Volume Editor : Teresa Carlomagno, Berlin, Springer, 2009, 1 vol. (XI- 331 p.), Topics in current chemistry, 978-3-540-69036-8 |
| LEADER | 04203nam a22004337a 4500 | ||
|---|---|---|---|
| 001 | 941573 | ||
| 008 | 090903q2000 xx ||| |||| 00| 0 eng d | ||
| 009 | PPN136300464 | ||
| 020 | |a 9783540690399 | ||
| 041 | 0 | |a eng | |
| 082 | |a 615.19 | ||
| 082 | |a 540 | ||
| 100 | 1 | |a Carlomagno, Teresa, |d 19..- | |
| 245 | 1 | 0 | |a Tubulin-Binding Agents : |b Synthetic, Structural and Mechanistic Insights |c edited by Teresa Carlomagno. |
| 250 | |a 1st ed. 2009. | ||
| 260 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg. | ||
| 260 | |a Cham : |b Springer Nature, |c [20..]. | ||
| 490 | 0 | |a Topics in Current Chemistry |v 286 |x 1436-5049 | |
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 505 | 1 | |a Macrolide-Based Microtubule-Stabilizing Agents Chemistry and Structure Activity Relationships The Chemical Synthesis of Discodermolide The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents | |
| 506 | |a Accès en ligne pour les établissements français bénéficiaires des licences nationales | ||
| 506 | |a Accès soumis à abonnement pour tout autre établissement | ||
| 506 | |a Conditions particulières de réutilisation pour les bénéficiaires des licences nationales. https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 | ||
| 520 | |a reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a time-resolved picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology | ||
| 650 | |a Chimie pharmaceutique | ||
| 650 | |a Cancer |x Recherche | ||
| 650 | |a Chimie | ||
| 650 | |a Chimie organique | ||
| 650 | |a Biochimie | ||
| 650 | |a Chimie analytique | ||
| 650 | |a Microtubules | ||
| 650 | |a Stabilisants | ||
| 776 | 0 | |0 135611261 |t Tubulin-binding agents |o synthetic, structural and mechanistic insights |f Volume Editor : Teresa Carlomagno |c Berlin |n Springer |d 2009 |p 1 vol. (XI- 331 p.) |s Topics in current chemistry |z 978-3-540-69036-8 | |
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| 856 | 4 | |u https://revue-sommaire.istex.fr/ark:/67375/8Q1-RH69Q3ZL-G |z Accès sur la plateforme Istex | |
| 856 | 4 | |5 452349901:747846065 |u https://ezproxy.univ-orleans.fr/login?url=https://dx.doi.org/10.1007/978-3-540-69039-9 |z Accès Université d'Orléans | |
| 856 | 4 | |5 180339901:750863579 |u https://ezproxy.insa-cvl.fr/login?qurl=https://dx.doi.org/10.1007/978-3-540-69039-9 |z Accès INSA CVL | |
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