Elements of Synthesis Planning
Synthesis is at the core of organic chemistry. In order for compounds to be studied be it as drugs, materials, or because of their physical properties they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involve...
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| Format: | Livre numérique |
| Jezik: | Anglais |
| Izdano: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| Online dostop: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
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Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
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| Edition sous un autre format: | • Elements of Synthesis Planning, R.W. Hoffmann., Berlin, Springer, 2009, 1 vol. (X-227 p.), 978-3-540-79219-2 |
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| 100 | 1 | |a Hoffmann, Rainer, |c chimiste. | |
| 245 | 1 | 0 | |a Elements of Synthesis Planning |c by R.W. Hoffmann. |
| 260 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg. | ||
| 260 | |a Cham : |b Springer Nature, |c [20..]. | ||
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 505 | 1 | |a Functional Group Oriented Bond-Sets Skeleton Oriented Bond-Sets Building Block Oriented Synthesis The Basis for Planning Formation of Cyclic Structures Protecting Groups Ranking of Synthesis Plans Computer-Aided Synthesis Planning Stereogenic Centers and Planning of Syntheses Enjoying the Art of Synthesis Summary and Concluding Remarks Solutions to Problems | |
| 506 | |a Accès en ligne pour les établissements français bénéficiaires des licences nationales | ||
| 506 | |a Accès soumis à abonnement pour tout autre établissement | ||
| 506 | |a Conditions particulières de réutilisation pour les bénéficiaires des licences nationales. https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 | ||
| 520 | |a Synthesis is at the core of organic chemistry. In order for compounds to be studied be it as drugs, materials, or because of their physical properties they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex natural products via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a one-pot operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield | ||
| 776 | 0 | |0 172223202 |t Elements of Synthesis Planning |f R.W. Hoffmann. |c Berlin |n Springer |d 2009 |p 1 vol. (X-227 p.) |z 978-3-540-79219-2 | |
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