Bioactive Conformation I
Speci?c binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term bioac...
שמור ב:
| מחבר ראשי: | |
|---|---|
| פורמט: | Livre numérique |
| שפה: | Anglais |
| יצא לאור: |
Berlin, Heidelberg :
Springer Berlin Heidelberg
[20..].
Cham : Springer Nature |
| מהדורה: | 1st ed. 2007. |
| סדרה: | Topics in Current Chemistry
272 |
| נושאים: | |
| גישה מקוונת: | Accès sur la plateforme de l'éditeur Accès sur la plateforme Istex Accès Université d'Orléans Accès INSA CVL |
| הערה: |
Archives Springer e-books (Licence nationale) Archives Springer e-books (Licence nationale) |
| Autres localisations: | Voir dans le Sudoc |
| Variante du titre: | With contributions by numerous experts |
| Edition sous un autre format: | • Bioactive conformation, I, volume editor : Thomas Peters, Berlin, Springer, 2007, 1 vol. (X-309 p.), Topics in current chemistry, 978-3-540-49077-7 |
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| 100 | 1 | |a Peters, Thomas. | |
| 240 | 1 | 0 | |a With contributions by numerous experts |
| 245 | 1 | 0 | |a Bioactive Conformation I |c edited by Thomas Peters. |
| 250 | |a 1st ed. 2007. | ||
| 260 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg. | ||
| 260 | |a Cham : |b Springer Nature, |c [20..]. | ||
| 490 | 0 | |a Topics in Current Chemistry |v 272 |x 1436-5049 | |
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 500 | |a Archives Springer e-books (Licence nationale) | ||
| 505 | 1 | |a Spatial Screening for the Identification of the Bioactive Conformation of Integrin Ligands Dynamics and Thermodynamics of Ligand Protein Interactions The Fibroblast Growth Factor (FGF) FGF Receptor Complex: Progress Towards the Physiological State Characterization of Interactions Between Misfolding Proteins and Molecular Chaperones by NMR Spectroscopy NMR Analysis of Bioprotective Sugars: Sucrose and Oligomeric (1?2)-?-D-glucopyranosyl-(1?2)-?-D-fructofuranosides Residual Dipolar Couplings Report on the Active Conformation of Rhodopsin-Bound Protein Fragments Glycosyltransferase Structure and Function Exploiting Ligand and Receptor Adaptability in Rational Drug Design Using Dynamics and Structure-Based Strategies | |
| 506 | |a Accès en ligne pour les établissements français bénéficiaires des licences nationales | ||
| 506 | |a Accès soumis à abonnement pour tout autre établissement | ||
| 506 | |a Conditions particulières de réutilisation pour les bénéficiaires des licences nationales. https://www.licencesnationales.fr/springer-nature-ebooks-contrat-licence-ln-2017 | ||
| 520 | |a Speci?c binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term bioactive conformation usually characterizes the conformation of a ligand when it is bound to a receptor. In a more general sense, bioactive conformation applies toanymoleculeinabiologicallyrelevantboundstateregardlessofsizecons- erations. Mostofthecontributions tothisbookaddressligandsthat aremuch smaller than their receptors. X-ray crystallography and high resolution NMR spectroscopy are the two main experimental techniques used to study bioactive conformations. The- fore,the twovolumes ofthisbookcover approachesthat use either ofthetwo techniques, or a combination thereof. The combination of X-ray crystallog- phy and NMR spectroscopy is particularly useful when a crystal structure of areceptorprotein,butnotofthereceptorprotein ligandcomplex,isavailable. Anumberofexperimentaltechniquestoanalyzethebioactiveconformationof aligandwithNMRarebasedontheobservationoftheresonancesignalsofthe free ligand that is in exchange with the bound ligand. Several chapters focus onsuchapproachesthat rangefrom classical transferredNOEexperiments, totransferreddipolarcouplings,toSTD(SaturationTransferDifference)NMR techniques. Incaseswhere tightbinding inthesub-nanomolar rangeprevents the analysis of the bioactive conformation via free ligand signals, the ligand protein complex has to be analyzed with protein NMR-based techniques or by crystallography. Since this area has been the subject of many reviews and monographs it will not be covered here in particular detail. As a unifying theme, all contributions target the question of how molecular recognition of biologically active molecules is achieved on the atomic scale | ||
| 650 | |a Biomolécules actives | ||
| 650 | |a Reconnaissance moléculaire | ||
| 650 | |a Chimie pharmaceutique | ||
| 650 | |a Spectroscopie de la résonance magnétique nucléaire | ||
| 650 | |a Radiocristallographie | ||
| 650 | |a Chimie | ||
| 650 | |a Complexes récepteur-ligand | ||
| 650 | |a Chimie organique | ||
| 650 | |a Ligands (biochimie) | ||
| 650 | |a Biochimie | ||
| 650 | |a Chimie physique et théorique | ||
| 650 | |a Ligands (biochimie) |x Fixation | ||
| 650 | |a Analyse conformationnelle | ||
| 650 | |a Conformation | ||
| 776 | 0 | |0 112295665 |t Bioactive conformation |h I |f volume editor : Thomas Peters |c Berlin |n Springer |d 2007 |p 1 vol. (X-309 p.) |s Topics in current chemistry |z 978-3-540-49077-7 | |
| 856 | 4 | |q PDF |u https://doi.org/10.1007/978-3-540-49078-4 |z Accès sur la plateforme de l'éditeur | |
| 856 | 4 | |u https://revue-sommaire.istex.fr/ark:/67375/8Q1-641KSRZN-B |z Accès sur la plateforme Istex | |
| 856 | 4 | |5 452349901:747895724 |u https://ezproxy.univ-orleans.fr/login?url=https://dx.doi.org/10.1007/978-3-540-49078-4 |z Accès Université d'Orléans | |
| 856 | 4 | |5 180339901:750908734 |u https://ezproxy.insa-cvl.fr/login?qurl=https://dx.doi.org/10.1007/978-3-540-49078-4 |z Accès INSA CVL | |
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