Leptospirosis and the kidney

Leptospirosis is the most common zoonotic disease worldwide, involving at least 1 million patients annually. Kidney is the preferential colonization site where Leptospira accumulates during systemic infection, primarily in the interstitium and in renal tubule epithelial cells. In acute kidney injury...

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Détails bibliographiques
Auteur principal: Yang, Chih-Wei
Autres auteurs: Pan, Ming-Jeng (Directeur de la publication), Yang, Huang-Yui (Directeur de la publication)
Format: Livre numérique
Langue:Anglais
Publié: Basel ; Paris : Karger 2019.
Basel : S. Karger AG
Collection:Translational Research in Biomedicine Volume 7
Sujets:
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Note: Karger ebooks (Licence nationale)
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100 1 |a Yang, Chih-Wei. 
245 1 0 |a Leptospirosis and the kidney   |c editors, Chih-Wei Yang, Ming-Jeng Pan, Huang-Yu Yang. 
256 |a Données textuelles 
260 |a Basel ;  |a Paris :  |b Karger. 
260 |a Basel :  |b S. Karger AG,  |c 2019. 
490 0 |a Translational Research in Biomedicine  |v Volume 7 
500 |a Karger ebooks (Licence nationale) 
504 |a Bibliographie en fin de chapitres. Index 
505 0 |a Leptospirosis and the kidney : an overview / Srisawat, N., Sitprija, V. -- Pathophysiology of leptospirosis kidney disease / Wu, M.-Y., Wu, M.-S. -- Leptospirosis-associated acute kidney injury / Lin, C.-Y. -- Leptospirosis and chronic kidney disease / Yang, H.-Y., Chang, C.-H., Yang, C.-W. -- Detection and treatment of leptospirosis kidney disease / Chiu, S.-H., Pan, M.-J. -- Innate immunity and kidney injury in leptospirosis / Hung, C.C. -- Leptospirosis and kidney fibrosis / Tian, Y.-C. -- Murine models for leptospirosis kidney disease / Werts, C. -- Zebrafish model for leptospirosis kidney disease / Chang, M.-Y., Cheng, Y.-C. -- Structural and functional biology approaches of leptospirosis kidney disease / Hsu, S.-H., Yang, C.-W. -- Systems biology approach to understanding leptospirosis kidney disease / Chou, L.-F., Yang, C.-W 
506 |a Conditions particulières de réutilisation pour les bénéficiaires des licences nationales. https://www.licencesnationales.fr/karger-ebooks-cctp-ln-2020 
506 |a Accès en ligne pour les établissements français bénéficiaires des licences nationales 
506 |a Accès soumis à abonnement pour tout autre établissement 
520 |a Leptospirosis is the most common zoonotic disease worldwide, involving at least 1 million patients annually. Kidney is the preferential colonization site where Leptospira accumulates during systemic infection, primarily in the interstitium and in renal tubule epithelial cells. In acute kidney injury (AKI), the main histological findings are acute tubulo-interstitial nephritis and acute tubular necrosis, characterized by hypokalemia and non-oliguria. The injury caused by leptospira outer membrane protein components involves innate immunity Toll-like receptor pathways and activation of complement and immune cascades in the kidney, together with extracellular matrix accumulation when the kidney infection progress to chronic kidney disease (CKD). Significantly, recent studies indicate that leptospira may induce CKD in humans either with AKI-CKD continuum or subclinical leptospira infection leading to CKD. Leptospirosis kidney disease thus represents a newly discovered and previously overlooked area requiring intensive medical and public health attention and investigation. In this book, leading experts in the field contribute their cutting-edge clinical and research experiences for the understanding of leptospirosis kidney disease.The outstanding feature of this publication is emphasizing kidney injury and disease induced by leptospirosis, an underestimated infection involving multiple organs. The book contributes information on current knowledge of leptospirosis kidney disease and a new perspective for future research 
538 |a Nécessite un navigateur internet ; lecteur de fichier EPUB ou PDF 
650 |a Maladies infectieuses 
650 |a Biologie moléculaire 
700 1 |a Pan, Ming-Jeng.  |4 pbd 
700 1 |a Yang, Huang-Yui.  |4 pbd 
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