Genetics of Bone Biology and Skeletal Disease
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model...
Bewaard in:
| Hoofdauteurs: | , , , |
|---|---|
| Formaat: | Livre numérique |
| Taal: | Anglais |
| Gepubliceerd in: |
Cambridge, MA :
Academic Press
2017.
Paris : Cyberlibris |
| Online toegang: | Accès Université d'Orléans et IFPM |
| Opmerking: |
Couverture. https://static2.cyberlibris.com/books_upload/300pix/9780128041987.jpg Cyberlibris (ScholarVox) corpus Santé |
| Autres localisations: | Voir dans le Sudoc |
| Edition sous un autre format: | • Genetics of Bone Biology and Skeletal Disease, Edited by Rajesh V. Thakker, Michael P. Whyte, John A. Eisman, [et autre], 2nd Edition, Cambridge, MA, Academic Press, 2017, 1 vol. (2103 p.), 978-01-2804-182-6 |
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| 009 | PPN291419259 | ||
| 020 | |a 9780128041987 | ||
| 041 | 0 | |a eng | |
| 100 | 1 | |a Thakker, Rajesh, |d 19..-...., |c médecin. | |
| 245 | 1 | 0 | |a Genetics of Bone Biology and Skeletal Disease |c Edited by Rajesh V. Thakker, Michael P. Whyte, John A. Eisman, [et autre]. |
| 260 | |a Cambridge, MA : |b Academic Press. | ||
| 260 | |a Paris : |b Cyberlibris, |c 2017. | ||
| 500 | |a Couverture. https://static2.cyberlibris.com/books_upload/300pix/9780128041987.jpg | ||
| 500 | |a Cyberlibris (ScholarVox) corpus Santé | ||
| 506 | |a L'accès en ligne est réservé aux établissements ou bibliothèques ayant souscrit l'abonnement. Cyberlibris | ||
| 520 | |a Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder | ||
| 700 | 1 | |a Whyte, Michael P. |4 aut | |
| 700 | 1 | |a Eisman, John A. |4 aut | |
| 700 | 1 | |a Igarashi, Takashi. |4 aut | |
| 776 | 0 | |t Genetics of Bone Biology and Skeletal Disease |f Edited by Rajesh V. Thakker, Michael P. Whyte, John A. Eisman, [et autre] |e 2nd Edition |c Cambridge, MA |n Academic Press |d 2017 |p 1 vol. (2103 p.) |z 978-01-2804-182-6 | |
| 856 | 4 | |5 452349901:867086181 |u https://ezproxy.univ-orleans.fr/login?url=https://univ.scholarvox.com/book/88972921 |z Accès Université d'Orléans et IFPM | |
| 997 | |0 1361327 |1 Livre numérique |a Ressource numérique |b INSA |b ENSA |c 0/Bibliothèque numérique/ |c 1/Bibliothèque numérique/ScholarVox (ebooks)/ | ||